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jwschmidt's profile

The Laboratory's current aim is to understand the structure, function and interactions of RNA on atomic and molecular level. The idea is to combine, within the Laboratory, chemistry, molecular biology, structural and calculation lines of research in the RNA field. Our particular areas of interest include: (i) structure of retroviral RNAs, their interactions and accessibility in view of RNAi, (ii) NMR RNA structure (iii) RNA structural databases (RNA FRABASE) and RNA 3D structure prediction (RNAComposer) both in collaboration with J. Blazewicz's Bioinformatics Laboratory.

Our group's goal is to understand the fundamental nature of catalysis by RNA enzymes (ribozymes). We study structure and function of small RNA catalysts with potential use in human gene therapy and as biosensors, as well as of large RNA-protein complexes, such as the ribosome, using fluorescence techniques in bulk solution, in live cells, and at the single-molecule level.

The RNA Society of North Carolina's mission is to promote communication and collaboration among individuals interested in the biological and chemical aspects of ribonucleic acid and to promote implementation of new technology resulting from research on all properties of RNA.

We are interested by all aspects of Ribosome Synthesis (RNA processing, RNA modification, pre-ribosome assembly and trafficking) in Eukaryotes.

We study pre-mRNA splicing in yeast. This occurs in an RNA-protein complex, the spliceosome, within which there are small ribonucleoprotein particles (snRNP), each composed of a small nuclear RNA (snRNA) and proteins. We investigate molecular interactions of these components.

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