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The Laboratory's current aim is to understand the structure, function and interactions of RNA on atomic and molecular level. The idea is to combine, within the Laboratory, chemistry, molecular biology, structural and calculation lines of research in the RNA field. Our particular areas of interest include: (i) structure of retroviral RNAs, their interactions and accessibility in view of RNAi, (ii) NMR RNA structure (iii) RNA structural databases (RNA FRABASE) and RNA 3D structure prediction (RNAComposer) both in collaboration with J. Blazewicz's Bioinformatics Laboratory.
Our group's goal is to understand the fundamental nature of catalysis by RNA enzymes (ribozymes). We study structure and function of small RNA catalysts with potential use in human gene therapy and as biosensors, as well as of large RNA-protein complexes, such as the ribosome, using fluorescence techniques in bulk solution, in live cells, and at the single-molecule level.
Jean Beggs Lab Home Page
We study pre-mRNA splicing in yeast. This occurs in an RNA-protein complex, the spliceosome, within which there are small ribonucleoprotein particles (snRNP), each composed of a small nuclear RNA (snRNA) and proteins. We investigate molecular interactions of these components.
RNA Structure, Catalysis and the Origin of Life
William Scott's research group that focuses on RNA Structure, Catalysis and the Origin of Life
RNA Secondary structure prediction, analysis and visualization.
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